This research is a synthesis of the political, legal, economic, social and health consequences characterizing the predicament of East Jerusalem and its residents followed by a focus on Kafr ‘Aqab as a case study. The peculiar situation of Kafr ‘Aqab, situated at the crossroads of the Israeli military Qalandia-checkpoint, inside Israeli defined greater Jerusalem, but physically dislocated outside the Separation Wall, serves to provide a window into the multiple layers of insecurity and fragmentation permeating Palestinian society. This qualitative investigation explores the impact of Israeli-imposed measures and restrictions on Palestinian family life, through the voices of Palestinians themselves; as well as in-depth interviews with experts and a participant observation at the Israeli-controlled Qalandia-checkpoint.